Yes, it is possible for you to submit a resignation letter within 24 hours even if you have only worked for two days and have signed an agreement. However, there are a few things that you need to consider. First, carefully review the agreement you have signed to check if there are any clauses related to resignation or notice period. If there is a notice period specified, you may be required to serve that period before your resignation takes effect. Second, contact your employer or the HR department as soon as possible to inform them about your situation and intention to resign. Be honest and explain the family matters that are preventing you from continuing the job. They will guide you through the resignation process and advise you on the necessary steps to take. It is important to maintain open and transparent communication with your employer to ensure a smooth transition and to avoid any potential legal or contractual issues. Ultimately, it will be up to your employer to accept your resignation on such short notice, but by following the appropriate procedure and showing understanding, they may be able to accommodate your request.